Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

A von Borstel; THO Nguyen; LC Rowntree; TM Ashhurst; LF Allen; LJ Howson; NE Holmes; OC Smibert; JA Trubiano; CL Gordon; AC Cheng; SJ Kent; J Rossjohn; K Kedzierska; MS Davey

Journal article

Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals

A von Borstel, THO Nguyen, LC Rowntree, TM Ashhurst, LF Allen, LJ Howson, NE Holmes, OC Smibert, JA Trubiano, CL Gordon, AC Cheng, SJ Kent, J Rossjohn, K Kedzierska, MS Davey

Immunology and Cell Biology | Published : 2023

DOI: 10.1111/imcb.12623

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27negCD45RA+CX3CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed..

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University of Melbourne Researchers

Oanh Nguyen Author

Louise Rowntree Author

Lauren J. Howson Author

Natasha Holmes Author

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Grants

Awarded by Hudson Institute of Medical Research

Funding Acknowledgements

This work was supported by an Australian Research Council (ARC) Discovery Early Career Researcher Award(DE200100292), a Rebecca L. Cooper Medical Research Foundation Project Grant (PG2020668), a Royal Society Wolfson Fellowship (RSWF/R2/222002) and an ARC Discovery Project (DP210103327) to MSD. National Healthand Medical Research Council of Australia (NHMRC) Leadership Investigator Grant to KK (1173871) and JR(2008981); NHMRC Emerging Leadership Investigator Grantor THON (1194036) and LJH (2007884); a Jack Brockhoff Foundation Early Career Research Grant to LJH (JBF4847-2021); Research Grants Council of the Hong Kong Special Administrative Region, China to KK (T11-712/19-N);the Victorian Government to SJK; MRFF award to SJK(2002073), KK (1202445), KK, ACC, and SJK (2005544), and KK, JR, THON, LR, and SJK (2016062); NHMRC program grant to SJK (1149990) and NIH contract CIVC-HRP to KK (HHS-NIH-NIAID-BAA2018).